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Opioid and Cannabinoid Pharmacokinetic Interactions
 Clinical Trial Study

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Information source: University of California, San Francisco
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pain; Neoplasms

Intervention: Cannabis (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University of California, San Francisco

Official(s) and/or principal investigator(s):
Donald I Abrams, M.D., Principal Investigator, Affiliation: University of California, San Francisco

Overall contact:
Paul Couey, Phone: 415-476-9554, Ext: 315, Email: pcouey@php.ucsf.edu


We are conducting a study to assess whether smoking marijuana affects the safety of prescribed opioids in patients treated for cancer-related pain. This study will assess whether smoking cannabis affects the absorption, distribution, metabolism and excretion of widely used opioid analgesics. We propose to do this by investigating the effects of smoked cannabis in subjects prescribed morphine or oxycodone for cancer-related pain. We will also assess the clinical safety of cannabinoids and these opioids by monitoring the short-term side effects associated with combined therapy.

Clinical Details

Official title: Opioid and Cannabinoid Pharmacokinetic Interactions: A Pilot Study

Study design: Treatment, Non-Randomized, Open Label, Active Control, Single Group Assignment, Pharmacokinetics Study

Primary outcome: To determine the effects of smoking cannabis on the disposition kinetics of morphine

Secondary outcome: To determine the effects of smoking cannabis on the disposition kinetics of oxycodone

Detailed description: Chronic pain conditions remain problematic, especially in patients with cancer. Although opioids are effective analgesics, dose-limiting side effects in the form of sedation, nausea and vomiting, and fear of dependence often limit their use at higher – and possibly more effective – doses. Of particular interest, however, is the potential for greater than additive analgesic effect of cannabinoids and opioids in combination that would allow for opioid analgesic effect to be achieved at lower dosages than are necessary alone, which could overcome problems with both tolerance and side effects for both drug classes. Unfortunately, safety data on the combination in humans does not exist at this time and needs to be obtained. As increasing numbers of patients with cancer may turn to cannabis to augment the effects of their opioid analgesics, data on potential pharmacokinetic interactions and clinical safety of the combinations should be evaluated in a controlled clinical research setting.



Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

1. Ongoing analgesic therapy with either oxycodone hydrochloride (OxyContinâ) or morphine sulfate (MS Continâ) every 12 hours for cancer pain.

2. Eligible subjects will be ³ 18 years of age with a diagnosis of cancer and an estimated survival of greater than six months.

3. Subjects must be on a stable dose of opioid medication for at least 2 weeks before enrollment.

4. Current other analgesic medications will be maintained during the study. The subject must have been on a stable medication regimen for at least 2 weeks.

5. The following laboratory parameters documented within 45 days prior to study entry:

– Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) £ 5 X upper

limit of normal (ULN)

– Total bilirubin £ 2 X ULN


– Creatinine £ 2. 0 mg/dL (177 µmol/L)

6. All men and women in this study must agree to use adequate birth control during this study. Acceptable barrier birth control methods are a male condom, female condom, diaphragm, or intra-uterine (IUD).

7. All women of reproductive potential (who have not reached menopause or undergone hysterectomy, oophorectomy, or tubal ligation) must have a negative urine b-HCG pregnancy test performed before initiating the protocol-specified medication.

8. Prior history of use of marijuana. Subjects must have smoked marijuana on at least 6 occasions in their lifetime prior to enrollment.

9. Able to understand and follow the instructions of the investigator, including completing the pain intensity rating scales.

10. Karnofsky Performance Score >60.

11. Able and willing to provide informed consent.

Exclusion Criteria:

1. Severe coronary artery disease, uncontrolled hypertension, cardiac ventricular conduction abnormalities, or orthostatic mean blood pressure drop greater than 24 mmHg, severe chronic obstructive pulmonary disease.

2. History of renal or hepatic failure.

3. Evidence of hepatic, hematological or renal dysfunction based on judgment of physician.

4. Active substance abuse (e. g., alcohol or injection drugs).

5. Use of smoked marijuana within 30 days of enrollment verified with a urine THC level.

6. Neurologic dysfunction or psychiatric disorder severe enough to interfere with assessment of pain or sensory systems.

7. Current use of smoked tobacco products or a confirmed cotinine level.

8. Women who are pregnant or breast-feeding may not take part in this study.

9. Unable to read or speak English.

Locations and Contacts

Paul Couey, Phone: 415-476-9554, Ext: 315, Email: pcouey@php.ucsf.edu

Community Consortium, San Francisco, California 94110, United States; Recruiting
Paul Couey, Phone: 415-476-9554, Ext: 315, Email: pcouey@php.ucsf.edu
Donald I Abrams, MD, Principal Investigator

Additional Information

Starting date: May 2006
Ending date: August 2008
Last updated: January 22, 2007

Page last updated: October 19, 2009

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