|
We Update Daily!
 Custom Search
Chris S. Kenoyer. Owner
MMJ Patient, Medical Activist,
Online Patients Advocate,
Online MMJ News Journalist
My Medical Bio
Follow Us Now On Twitter
@MedicalMMJMan
Or Follow Us Now
On Facebook
Email Us Here
olpwebs@yahoo.com
Or Email Us Securely Here
MedicalMMJMan@countermail.com
NEW 100% Encrypted Email Server
OLP’s Free MMJ News EList
Get The Latest In MMJ News
Press Contact Info
Is CBD? A Possible Cure For
Breast Cancer..? And All The Other
Many Forms & Types Of Cancer..?
Learn More About CBD Here
***************************
Advertise Here On OnlinePot
Rates As Low As $50 a Year
24/7 – 365 Days A Year Of Sales!
***********************************
Website Navigational Links
Main Start Page 2
**************************
Latest Marijuana News Reports
*********************************
Parody’s Cartoons US
Government Grown Pot,
Term Papers, School
Reports, & Thesis’s On
Marijuana & Cannabis
*********************************
Amsterdam A to Z
********************************
Canadian Marijuana Websites
*******************************
Church’s & Pot Cannabis
*****************************
Co-Ops, Clinics, Dispensary’s
*****************************
Marijuana Doctors & Clinics
****************************
Pot Cooking Recipes
****************************
Drug Testing A To Z
***************************
Pot Games
****************************
Pot Songs Video’s
****************************
100’s Of Grow Guides
***************************
Hash A- Z
***************************
Cannabis Legal Info, Drug
Lawyers, State, Federal Laws,
State & Supreme Court Rulings
**********************
POW’s Of The MMJ War!
*****************************
Other Marijuana Websites
Reciprocal Link Exchange
****************************
Medical Marijuana Studies,
Research Report’s, Medical
Cannabis Clinic Study’s
****************************
Parody’s & Cartoons
When We All Need A Good Laugh!
****************************
Avoiding Online MOM Scammers
Newly Re-Updated Info!
*****************************
The Politics Of Contraband
Medical Marijuana In The Mail?
******************************
The Hall Of Shame Section
The Online MOM Scammers
*****************************
Online MOM Providers Ads
****************************
Politicians & Voters Rights
****************************
Medical Marijuana, Strains
****************************
The OG Marijuana Strain Guide
****************************
800+ FAQ Growing Questions
****************************
Patients Spiritual Guidance,
Free Online Crisis Help Center
****************************
Online Marijuana Seed Banks
****************************
Maximum Security Section
Just Updated!
*****************************
Traveling Tips, Guides, B & B’s
****************************
Vaporizers A To Z
*****************************
Online Pot Video’s & Movies
**********************************************
Please Visit Both Of Our Sister Websites!
Maine Patients Coalition.org
The Reefer Madness Teaching Museum.org
Listen Right Here Online!
To Original 1930-1950’s
Reefer Madness Propaganda
Radio Shows And Programs
Before TV There Were
"Radio Stars"
*********************************
Legal Disclaimer
Guest Book
Translate Text or Web Page Go To:
Language Tools Google Translations
Article Submissions & News
Reports Are Always Gladly
Accepted Here.
No part of this site maybe used or
reproduced in whole or in part
without the written consent of the
Copyright Owner
www.onlinepot.org
OLP ENTERPRISES L3C
1999-2014 Copyright
© All rights reserved
OnlinePot assumes no legal liability for any products, or information or
news posted, services offered, Or
any contests or give away’s offered.
|
|
GABA deficits disturb endocannabinoid system, Research Study.
Changes in the endocannabinoid system may have important implications for psychiatric and
addiction disorders. This brain system is responsible for making substances that have effects
on brain function which resemble those of cannabis products, e.g., marijuana.
Return Back To OnlinePot’s Main Medical Page
GABA deficits disturb endocannabinoid system
January 24, 2012
Changes in the endocannabinoid system may have important implications for psychiatric and addiction disorders. This brain system is responsible for making substances that have effects on brain function which resemble those of cannabis products, e.g., marijuana.
The endocannabinoid system is of particular interest in the field of schizophrenia research because exposure to cannabis products during adolescence and young adulthood appears to increase the risk for developing schizophrenia. Also, in studies examining brain tissue collected from people who had schizophrenia, changes in the endocannabinoid system were highly correlated with changes in the principal inhibitory chemical messenger system in the brain, the gamma-aminobutyric acid (GABA) system.
The current study was conducted in order to research the relationship between changes in the GABA system and changes in the endocannabinoid system. Led by Dr. David Lewis at the University of Pittsburgh, researchers made genetic manipulations in mice that selectively reduced the GABA system function by decreasing the expression of the enzyme that makes GABA, GAD67, or by decreasing the expression of the principal receptor target for endocannabinoids in the brain, the cannabinoid 1 receptor (CB1R), in order to determine whether a change in one is sufficient to cause a change in the other.
Using these techniques, the researchers demonstrated that reduced expression of GAD67 can lead to reduced expression of CB1R, but not vice versa.
"Because activation of the CB1R suppresses GABA release, lower levels of CB1R may help augment GABA release from nerve terminals that have below normal amounts due to reduced GABA synthesis," said Dr. Lewis of the results. "This evidence suggests that reduced GABA signaling is an ‘upstream’ event in the disease process of schizophrenia and that lower CB1R is a compensation to help normalize GABA signaling."
These findings indicate that GABA abnormalities in schizophrenia are what trigger the disturbances in the endocannabinoid system. Importantly, cannabis use also alters GABA activity in the brain.
"While the whole story is still developing, from these data, it looks like developmental deficits in GABA systems are sufficient to disturb the function of the endocannabinoid system. This could be an important clue to the link between cannabis use and psychosis," commented Dr. John Krystal, editor of Biological Psychiatry.
Additional research will be necessary to further explore such links, including investigations into whether and/or how cannabis exposure affects the relationship between GAD67 and CB1R.
More information: The article is "Cortical Glutamic Acid Decarboxylase 67 Deficiency Results in Lower Cannabinoid 1 Receptor Messenger RNA Expression: Implications for Schizophrenia" by Stephen M. Eggan, Matthew S. Lazarus, Samuel R. Stoyak, David W. Volk, Jill R. Glausier, Z. Josh Huang, and David A. Lewis (doi: 10.1016/j.biopsych.2011.09.014) (http://www.biologicalpsychiatryjournal.com/article/S0006-3223%2811%2900911-5/abstract). The article appears in Biological Psychiatry, Volume 71, Issue 2 (January 15, 2012)
Provided by Elsevier
http://medicalxpress.com/news/2012-01-gaba-deficits-disturb-endocannabinoid.html
Return Back To OnlinePot’s Main Medical Page
|
Button Ads! 