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Science: Cannabidiol CBD beneficial in social anxiety disorder in a small clinical study
A small clinical study was conducted at the Division of Psychiatry of the University of São Paulo, Brazil, with 10 patients suffering from generalized social anxiety disorder. In the first session, subjects were given an oral dose of cannabidiol (CBD) (400 mg) or placebo, in a double-blind procedure. In the second session, the same procedure was performed using the drug that had not been administered in the previous session. Regional cerebral blood flow at rest was measured by an established method (Single Photon Emission Computed Tomography, SPECT) during each session.
Relative to placebo, CBD was associated with significantly decreased subjective anxiety. CBD also caused changes in regional cerebral blood flow. Researchers concluded that "these results suggest that CBD reduces anxiety in SAD [social anxiety disorder] and that this is related to its effects on activity in limbic and paralimbic brain areas."
(Source: Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran F, Marti N-Santos RO, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan Z, Santos Filho A, Freitas-Ferrari MC, McGuire P, Zuardi AW, Busatto G, Hallak JE. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol. 2010 Sep 9. [in press])
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