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Study: Vaporized Cannabis Augments The Analgesic Effects Of Opiates
In Human Subjects


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Thursday, 10 November 2011

San Francisco, CA: Cannabis administration significantly augments the
analgesic effects of opiates in patients with chronic pain, according
to clinical trial data published online in the journal Clinical
Pharmacology & Therapeutics.

Investigators at the University of California, San Francisco assessed
the use of vaporized cannabis over a five-day period in 21 chronic
pain subjects who were on a regimen of twice-daily doses morphine or
oxycodone. Participants in the trial inhaled cannabis vapor on the
evening of day 1 of the study, three times a day on days 2 through 4,
and in the morning of day 5. Subjects’ extent of chronic pain was
assessed daily.

Researchers determined that subjects’ pain "was significantly
decreased after the addition of vaporized cannabis" and surmised that
cannabis-specific interventions "may allow for opioid treatment at
lower doses with fewer [patient] side effects."
They concluded: "The participants experienced less pain after 5 days
of inhaling vaporized cannabis; when the morphine and oxycodone
groups were combined, this reduction in pain was significant. This is
the first human study to demonstrate that inhaled cannabis safely
augments the analgesic effects of opioids. … These results suggest
that further controlled studies of the synergistic interaction
between cannabinoids and opioids are warranted."

 Full text of the study, "Cannabinoid-Opioid interaction in chronic pain," 
appears in Clinical Pharmacology & Therapeutics.

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