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Topical application of a natural
 endocannabinoid effective in 
reducing pruritus in clinical study

                  Science:

           Posted 7th August 2006

Researchers of the University of Munster, Germany, conducted  an open study with N-palmitoyl ethanolamine (PEA) in 22 patients with severe pruritus (itching) of several causes. PEA 
was applied in an emollient cream to the skin. It is an 
endocannabinoid that binds to cannabinoid receptors such as THC and other cannabinoids. These receptors are present in the skin. 

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In 14 of the 22 patients a good antipruritic effect could be 
documented. The average reduction in itch was 86.4 per cent. 
The therapy was well-tolerated by all patients without local or 
general side effects. Researchers concluded that "topical 
cannabinoid agonists represent a new effective and well-
tolerated therapy for refractory itching of various origins. 
Creams with a higher concentration may be even more effective 
with broader indications."

(Source: Stander S, Reinhardt HW, Luger TA. [Topical 
cannabinoid agonists : An effective new possibility for treating 
chronic pruritus.] [Article in German] Hautarzt. 2006 Jul 28; 
[Electronic publication ahead of print])

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