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THC Marijuana tested against
brain tumors in pilot clinical study
Results of a clinical study with THC in nine brain cancer patients conducted
in
a hospital on Tenerife, Spain, were published in the British Journal of
Cancer.
Patients suffered from a gioblastoma, a very aggressive brain
tumor, and
had previously failed standard therapy (surgery and
radiotherapy). Median
survival was 24 weeks. Two patients survived nearly
one year.
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THC was administered directly into the tumor by a small catheter, whose tip was
placed into the tumor during a surgery. The initial THC dose was 20-40
micrograms, which was increased to 80-180 micrograms daily. Patients were
treated for 10-64 days. The treatment was well tolerated by all patients.
The tumors of the nine patients expressed different amounts of CB1 and CB2
receptors, but there was no correlation between receptor expression and
survival. Due to the study design it was not possible to determine the effect of
THC on survival. This would have required a control group with no or with a
different
treatment. A comparison with survival in pilot studies with other drugs suggests
that THC may have been beneficial to the patients in this study. Researchers
noted that THC at least did
"not facilitate tumor growth nor decrease patient survival." They
suggest further trials with cannabinoids on this and other types of
tumors either alone or in combination with other anti-tumoral drugs.
(Source: Guzman M, Duarte MJ, Blazquez C, Ravina J, Rosa MC, Galve-Roperh I,
Sanchez C, Velasco G, Gonzalez-Feria L. A pilot clinical study of
Delta(9)-tetrahydrocannabinol in
patients with recurrent glioblastoma multiforme. Br J Cancer, 2006 Jun 27;
[electronic publication ahead of print])
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