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Marijuana Cannabis Component
Slows Diabetes in Research Study
Marijuana Cannabis Chemical Reduces
the Development of Diabetes in Animal
Study
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Back To Main Medical Reports Page
Researchers of the Hadassah University Hospital of Jerusalem investigated
the effects of the plant cannabinoid cannabidiol (CBD) on the development of
diabetes in mice, which develop diabetes due to genetic causes. So-called
NOD mice develop insulitis within 4 to 5 weeks of age followed by diabetes
within a median of 14 weeks. Insulitis is an inflammation of the cells in
the pancreas that produce insulin, and diabetes is a result of a destruction
of these cells.
NOD mice aged 6 to 12 weeks that were treated with 10 to 20 injections of
CBD (5 mg per kilogram body weight) presented with a significantly reduced
incidence of diabetes of 30 per cent compared to 86 per cent in untreated
control mice. In addition, in the mice that developed diabetes in the
treated group disease onset was a significantly delayed. Blood levels of two
cytokines that promote inflammation, IFN-gamma and TFN-alpha, are usually
increased in NOD mice. A treatment with CBD caused a significant reduction
(more than 70 per cent) in levels of both cytokines. In another experiment
CBD-treated mice were observed for 26 weeks. While the 5 control mice all
developed diabetes, 3 of 5 of the CBD-treated mice remained diabetes- free
at 26 weeks.
Researchers concluded that confirmation of the observed immunomodulatory
effects of CBD "may lead to the clinical application of this agent in the
prevention of type 1 diabetes" and possibly other autoimmune diseases. They
note that many patients diagnosed with type 1 diabetes have sufficient
residual cells that produce insulin at the time of diagnosis, and may be
candidates for immunomodulation therapy.
Source: Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily
R. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.
Autoimmunity 2006;39(2):143-51.
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