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Study shows marijuana
increases brain cell growth
ST. JOHN’S, Nfld — Supporters of
marijuana may finally have an excuse to smoke weed every day. A recent study in
the Journal of Clinical Investigation suggests that smoking pot can make the
brain grow.
By Juanita King, The Muse (Memorial University of Newfoundland)
August 26th
2006
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Though most drugs inhibit the growth of new brain cells, injections of a
synthetic cannibinoid have had the opposite effect in mice in a study performed
at the University of Saskatchewan. Research on how drugs affect the brain has
been critical to addiction treatment, particularly research on the hippocampus.
The hippocampus is an area of the brain essential to memory formation. It is
unusual because it grows new neurons over a person’s lifetime. Researchers
believe these new cells help to improve memory and fight depression and mood
disorders.
Many drugs -— heroin, cocaine, and the more common alcohol and nicotine —
inhibit the growth of these new cells. It was thought that marijuana did the
same thing, but this new research suggests otherwise.
Neuropsychiatrist Xia Zhang and a team of researchers study how marijuana-like
drugs — known collectively as cannabinoids — act on the brain.
The team tested the effects of HU-210, a potent synthetic cannabinoid similar to
a group of compounds found in marijuana. The synthetic version is about 100
times as powerful as THC, the high-inducing compound loved by recreational
users.
The researchers found that rats treated with HU-210 on a regular basis showed
neurogenesis — the growth of new brain cells in the hippocampus. A current
hypothesis suggests depression may be triggered when the hippocampus grows
insufficient numbers of new brain cells. If true, HU-210 could offer a treatment
for such mood disorders by stimulating this growth.
Whether this is true for all cannabinoids remains unclear, as HU-210 is only one
of many and the HU-210 in the study is highly purified.
“That does not mean that general use in healthy people is beneficial,” said
Memorial psychology professor William McKim. “We need to learn if this happens
in humans, whether this is useful in healthy people, and whether THC causes it
as well.”
McKim warns that marijuana disrupts memory and cognition. “These effects can
be long-lasting after heavy use,” he said. “This makes it difficult to
succeed academically if you use it excessively.”
“Occasional light use probably does not have very serious consequences. [But]
there is some evidence that marijuana smoke might cause cancer.” 
Still, the positive aspects of marijuana are becoming more plentiful as
further research is done. McKim says it’s not surprising that THC and
compounds like it could have medicinal effects.
“Many have been identified,” he said. “It stimulates appetite in people
with AIDS, it is an analgesic, and blocks nausea in cancer patients undergoing
chemotherapy. And it treats the symptoms of glaucoma.”
The research group’s next studies will examine the more unpleasant side of the
drug.
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