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Nabilone effective in the treatment
of chronic pain in clinical study
Science:
Physicians at a hospital in Vienna, Austria, conducted a placebo- controlled
clinical study with nabilone in 30 patients who
suffered from chronic
therapy-resistant pain.
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Back To Main Medical Reports Page
Posted August 7th 2006
During a 14 week period patients received nabilone and placebo each
for four weeks in addition to their standard medication. Participants
chose the dosage of the study drug themselves, between 1 and 4
capsules corresponding to 0.25-1 mg nabilone or placebo per
day. In the following 16 weeks patients were allowed to freely
choose their prefered drug (test drug A or B).
Nabilone is a synthetic cannabinoid with similar effects as the
natural cannabinoid THC. The intake of nabilone was associated
with a significant decrease in pain intensity of spinal origin, with a
significant decrease of average headache intensity, and with an
increase in quality of life. The number of study participants who
favoured nabilone was more than 4 times higher than those who
favoured placebo.
Researchers concluded "that a majority of patients with chronic
pain classify nabilone intake in addition to the standard treatment
as a measure with a positive individual benefit-risk-ratio. Thus,
this kind of treatment may be an interesting and attractive
enrichment of analgetic therapy concepts."
(Source: Pinsger M, Schimetta W, Volc D, Hiermann E,
Riederer F, Polz W. [Benefits of an add-on treatment with the
synthetic cannabinomimetic nabilone on patients with chronic
pain - a randomized controlled trial.] [Article in German] Wien
Klin Wochenschr 2006;118(11-12):327-35)
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