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Endocannabinoid System Plays Significant
Role In Embryonic Development, Study Says
Nashville, TN: The endocannabinoid system plays a
significant role in the development of healthy embryos
and their implantation in the womb, according to
pre-clinical data published this month in the Journal
of Clinical Investigation.
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Back To Main Medical Reports Page
August 3rd 2006
Researchers at Vanderbilt University in Tennessee reported that experimentally
inducing elevated amounts of the endogenous cannabinoid anadamide and/or THC in
newly mated mice "deferred on-time [embryo] implantation" and was associated with
"poor pregnancy outcome."
Previous preclinical studies investigating the role of endogenous cannabinoids in
prenatal development have shown that the body temporarily reduces the localized
production of anadamide during embryonal implantation. Though some researchers
speculate that smoking large quantities of cannabis during this period could
negatively impact this biological process, there is - to date - a lack of clinical
or epidemiological data supporting the theory.
"Nevertheless, it is apparent that a properly functioning endocannabinoid system is
essential for both a healthy pregnancy and child," NORML Senior Policy Analyst Paul
Armentano said.
Previous studies indicate that the endogenous cannabinoid system plays a primary
role in the development of memory and oral motor skills in newborns. Some
researchers theorize that a dysfunctional endocannabinoid system (such as one that
under produces anandamide) may be responsible for the development of certain
abnormalities in infants - particularly so-called 'failure-to-thrive' syndrome, a
condition in which newborns fail to properly grow and gain weight. In preclinical
trials, infant mice fail to feed from their mothers when their cannabinoid receptors
are blocked by the presence of a synthetic antagonist.
In recent years, scientists have determined that the endocannabinoid receptor system
is involved in the regulation of several primary biological functions including
appetite, body temperature, mood elevation, blood pressure, bone density,
reproductive activity, learning capacity, and motor coordination.
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