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Cannabis counters brain cell damage after a stroke
Researchers from the Medical School's Department of Pharmacology
and
Toxicology have been the first in the world to show the
cannabinoid CB2 receptor
appears in the rat brain following a stroke.
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Back To Main Medical Reports Page

Their findings were published recently in the journal Neuroscience Letters.
Dr John Ashton says the CB2 receptor is a protein produced as part of the body's
immune response system.
"This response is triggered by stroke and causes the inflammation that
leads to da mage in the area of the brain around where the stroke has occurred.
"If the inflammation can be stopped or reduced then it offers the hope of
reducing the extent of the da mage caused by stroke - and CB2 offers a potential
target for such a drug."
Dr Ashton says cannabis targets both the CB2 and the related CB1 receptors.
"THC, the major active ingredient of cannabis, acts mainly on CB1 but it
also affects CB2. While THC is known to have some positive effects in terms of
pain management its use is severely limited because of the way it triggers the
psychoactive CB1 receptors in the brain," he says.
"The aim would be to develop a drug that targets the CB2 receptor without
affecting CB1."
Dr Ashton says the relationship between cannabis and cannabinoid drugs has
similarities to the relationship between heroin and codeine.
"Heroin and codeine share common targets, but by designing codeine in such
a way that it eliminated the psychoactive side-effects seen with heroin, a
therapeutically useful drug was developed. There is the potential to do the same
with cannabinoids."
Drugs targeting CB2 could also have potential therapeutic use in other
conditions involving inflammatory da mage to the brain, such as Huntington's
Disease and Alzheimer's Disease. There may also be scope to use them in pain
management.
"CB2 cells are also found in the spinal cord. They regulate pain signals
making them a potential target for new pain ki lling drugs."
http://www.spiritindia.com/health-care-news-articles-8372.html
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