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Smokeless Cannabis Vaporizers Delivery
Systems Found Safer And Effective
Research Study Proves San Francisco, CA: Vaporization is a safer and effective
cannabinoid delivery mode for patients who desire the rapid onset of action associated with inhalation while avoiding the respiratory risks of smoking, according to clinical trial data to be published in the journal Clinical Pharmacology Therapeutics.
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4-18-07
Investigators at San Francisco General Hospital
reported that use of the Volcano vaporizing
device delivered doses of THC to
subjects in a manner while
significantly reducing their intake of gaseous
combustion toxins, including carbon monoxide.
Eighteen subjects participated in the six-day
study, which was sponsored by the state of
California and the Center
for Medicinal Cannabis Research.
http://www.cmcr.ucsd.edu/geninfo/index.htm
Vaporization of marijuana does not result in
exposure to combustion gases, ... and [was]
preferred by most subjects compared to marijuana
cigarettes, authors concluded. & The Volcano
[vaporizer] device is an effective and apparently
safe vehicle for THC delivery, and warrants
further investigation in clinical trials of
cannabis for medical purposes.
Researchers reported that vaporization resulted
in higher plasma concentrations of THC compared
to smoked cannabis for up to 60 minutes following
inhalation. Investigators also reported that
subjects 'self-titrated' their intake of cannabis
vapor, taking smaller and less frequent puffs
when exposed to stronger marijuana. On average,
the Volcano vaporizer exposed subjects to 54
percent of the applied dose of THC.
http://www.maps.org/news-letters/v06n3/06359mj1.html
Previous studies have shown that as much as 80 percent of
the THC burned in cigarettes or water-pipes is
lost in slipstream smoke.
A www.norml.org/index.cfm?Group_ID=6885
clinical trial assessing the safety and efficacy
of the Volcano vaporizer published in 2006 in the
Journal of Pharmaceutical Sciences also reported
that the device delivers set doses of THC to
subjects in a reproducible manner & while avoiding
the respiratory disadvantages of smoking. The
efficacy of the Volcano vaporizer was initially
reported in a study co-sponsored by NORML
http://www.canorml.org/healthfacts/vaporizerstudy2.html
and the Multidisciplinary Association for Psychedelic Studies (MAPS), which
found that the device delivered vapor of high
purity with practically no toxic tars or
hydrocarbons.
Vaporization heats cannabis to a temperature
where active cannabinoid vapors form (typically
around 180-190 degrees Celsius), but below the
point of combustion where noxious smoke and
associated toxins (i.e., carcinogenic
hydrocarbons) are produced (above 230 degrees
Celsius).
Separate survey data published this week in the
Harm Reduction Journal also reports that
vaporization is subjectively associated with
fewer respiratory symptoms than smoking cannabis.
Abstracts of the study, & Decreased respiratory
symptoms in cannabis users who vaporize,& are
available online at:
http://www.harmreductionjournal.com/content/4/1/11/abstract
Pot's Active Ingredient Halts Lung Cancer Growth, Study Says
Los Angeles, CA: The
administration of THC significantly reduces lung
tumor size and lesions, according to preclinical
data presented this week at the annual meeting of
the American Association for Cancer Research
(AACR) in Los Angeles.
Investigators at Harvard University's Division of
Experimental Medicine reported that THC inhibited
the growth and spread of cells in vitro from two
different lung cancer cell lines and from patient
lung tumors. They also reported that THC
administration reduced the growth of lung tumors
in mice by more than 50 percent compared to
untreated controls over a three-week period.
Researchers noted that THC appeared to block a
specific cancer-causing protein in a manner
similar to the pharmaceutical anti-cancer drugs
Erbitux (Cetuximab) and Vectibix (Panitumumab).
Results of a large-scale, case-controlled
http://www.norml.org/index.cfm?Group_ID=6912
study published last year found that smoking
cannabis, even long-term, is not positively
associated with increased incidence of
lung-cancer. Investigators in that study noted
that one subset of moderate lifetime users had an
inverse association between cannabis use and lung
cancer, leading them to speculate that
cannabinoids may possess certain protective
properties against the development of lung cancer
in humans.
Separate http://www.norml.org/index.cfm?Group_ID=7008
pre-clinical studies indicate that compounds in marijuana
inhibit cancer cell growth in animals and in
culture on a wide range of tumoral cell lines --
including human breast carcinoma cells, human
prostate carcimona cells, and human colectoral
carcinoma cells, among others. Most recently,
investigators at Madrid's Complutense University,
School of Biology, reported in the British
Journal of Cancer that
http://www.norml.org/index.cfm?Group_ID=6947
administration decreases recurrent glioblastoma multiforme
(brain) tumor growth in patients diagnosed with the disease.
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