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THC effective in the treatment of schizophrenia in four case reports
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Back To Main Medical Reports Page
In a letter to the editor of the Journal of Clinical Psychiatry
doctors of the Rockland Psychiatric Center in Orangeburg, New York,
USA, reported of four more patients with schizophrenia not responding
to other medication, who improved considerably with a treatment by
THC. The physicians had already published a similar experience with
four other patients in 2009. This time they tried dronabinol (THC)
for 8 further patients in the hospital. They all suffered from severe
psychosis refractory to standard medication and reported of a
positive previous experience with cannabis. There were four
responders with good improvement with THC and four non-responders.
One case was a 54-year-old man with schizoaffective disorder, who had
been aggressive, intrusive, and disorganized for years in spite of
multiple medication trials. Before the THC trial he received daily
clozapine, risperidone, lithium carbonate, and clonazepam for months
with no significant benefit. After adding 5 mg THC twice a day he
became calm, cooperative, and logical and was very much improved, as
did the other three responders. None of the four non-responders had a
worsening of their psychosis or other effects. Authors noted, that
they "simply had no change with the addition of dronabinol." They
write: "We suspect that in a small subsect of these [psychotic]
patients, the etiology of their psychosis is low endogenous
endocannabinoid brain function, so that cannabinoid stimulation would
improve their behavior."
(Source: Schwarcz G, Karajgi B. Improvement in refractory psychosis
with dronabinol: four case reports. J Clin Psychiatry
2010;71(11):1552-3.) 12-05-2010
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