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Cannabis extract Sativex effective in bladder dysfunction in
clinical study
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At hospitals in the UK and Belgium 135 patients with multiple
sclerosis and overactive bladder were included in a double-blind
placebo-controlled, parallel-group trial to study the effect of the
cannabis extract Sativex. During 8 weeks they received either the
extract or a placebo.
There was only little difference between the cannabis extract and
placebo on the primary endpoint, the reduction in daily number of
urinary incontinence episodes from baseline to end of treatment.
Four out of seven secondary endpoints were significantly in
favour of Sativex: number of episodes of urinations (voids) during
the night, overall bladder condition, number of voids/day and
Patient's Global Impression of Change. Authors concluded:
"Although the primary endpoint did not reach statistical
significance, we conclude that Sativex did have some impact on
the symptoms of overactive bladder in patients with MS, providing
evidence of some improvement in symptoms associated with
bladder dysfunction in these subjects."
(Source: Kavia RBC, De Ridder D, Constantinescu CS, Stott CG,
Fowler CJ. Randomized controlled trial of Sativex to treat
detrusor overactivity in multiple sclerosis. Mult Scler 2010 Sept 9
[in press])
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