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Science: Cannabidiol CBD beneficial in social anxiety disorder
in a
small clinical study
A small clinical study was conducted at the Division of Psychiatry
of the University of São Paulo, Brazil, with 10 patients suffering
from generalized social anxiety disorder. In the first session,
subjects were given an oral dose of cannabidiol (CBD) (400 mg)
or placebo, in a double-blind procedure. In the second session, the
same procedure was performed using the drug that had not been
administered in the previous session. Regional cerebral blood flow
at rest was measured by an established method (Single Photon
Emission Computed Tomography, SPECT) during each session.
Relative to placebo, CBD was associated with significantly
decreased subjective anxiety. CBD also caused changes in
regional cerebral blood flow. Researchers concluded that "these
results suggest that CBD reduces anxiety in SAD [social anxiety
disorder] and that this is related to its effects on activity in limbic
and paralimbic brain areas."
(Source: Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L,
Duran F, Marti N-Santos RO, Simões MV, Bhattacharyya S,
Fusar-Poli P, Atakan Z, Santos Filho A, Freitas-Ferrari MC,
McGuire P, Zuardi AW, Busatto G, Hallak JE. Neural basis of
anxiolytic effects of cannabidiol (CBD) in generalized social
anxiety disorder: a preliminary report. J Psychopharmacol. 2010
Sep 9. [in press])
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