We Update Daily!
Custom Search
Chris S. Kenoyer. Owner MMJ Patient, Medical Activist, Online Patients Advocate, Online MMJ News Journalist
My Medical Bio
Follow Us Now On Twitter @MedicalMMJMan
Or Follow Us Now On Facebook
Email Us Here olpwebs@yahoo.com
Or Email Us Securely Here MedicalMMJMan@countermail.com NEW 100% Encrypted Email Server
OLP’s Free MMJ News EList Get The Latest In MMJ News
Press Contact Info
Is CBD? A Possible Cure For Breast Cancer..? And All The Other Many Forms & Types Of Cancer..? Learn More About CBD Here
***************************
Advertise Here On OnlinePot Rates As Low As $50 a Year 24/7 – 365 Days A Year Of Sales!
***********************************
Website Navigational Links
Main Start Page 2
**************************
Latest Marijuana News Reports
*********************************
Parody’s Cartoons US Government Grown Pot, Term Papers, School Reports, & Thesis’s On Marijuana & Cannabis *********************************
Amsterdam A to Z ********************************
Canadian Marijuana Websites *******************************
Church’s & Pot Cannabis
*****************************
Co-Ops, Clinics, Dispensary’s *****************************
Marijuana Doctors & Clinics ****************************
Pot Cooking Recipes ****************************
Drug Testing A To Z ***************************
Pot Games
****************************
Pot Songs Video’s ****************************
100’s Of Grow Guides ***************************
Hash A- Z
***************************
Cannabis Legal Info, Drug Lawyers, State, Federal Laws, State & Supreme Court Rulings **********************
POW’s Of The MMJ War!
*****************************
Other Marijuana Websites Reciprocal Link Exchange ****************************
Medical Marijuana Studies, Research Report’s, Medical Cannabis Clinic Study’s ****************************
Parody’s & Cartoons When We All Need A Good Laugh!
****************************
Avoiding Online MOM Scammers Newly Re-Updated Info! *****************************
The Politics Of Contraband Medical Marijuana In The Mail? ******************************
The Hall Of Shame Section The Online MOM Scammers *****************************
Online MOM Providers Ads ****************************
Politicians & Voters Rights ****************************
Medical Marijuana, Strains ****************************
The OG Marijuana Strain Guide ****************************
800+ FAQ Growing Questions ****************************
Patients Spiritual Guidance, Free Online Crisis Help Center ****************************
Online Marijuana Seed Banks ****************************
Maximum Security Section Just Updated! *****************************
Traveling Tips, Guides, B & B’s ****************************
Vaporizers A To Z *****************************
Online Pot Video’s & Movies **********************************************
Please Visit Both Of Our Sister Websites!
Maine Patients Coalition.org
The Reefer Madness Teaching Museum.org
Listen Right Here Online! To Original 1930-1950’s Reefer Madness Propaganda Radio Shows And Programs Before TV There Were "Radio Stars"
*********************************
Legal Disclaimer
Guest Book
Translate Text or Web Page Go To: Language Tools Google Translations
Article Submissions & News Reports Are Always Gladly Accepted Here.
No part of this site maybe used or reproduced in whole or in part without the written consent of the Copyright Owner www.onlinepot.org
OLP ENTERPRISES L3C 1999-2014 Copyright © All rights reserved
OnlinePot assumes no legal liability for any products, or information or news posted, services offered, Or any contests or give away’s offered.
|
|
Medical Research Study: How Marijuana Impairs Memory
Han et al.: Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD.
Return Back To OnlinePot’s Main Medical Page
Public release date: 1-Mar-2012
Medical Research Study: How Marijuana Impairs Memory
A major downside of the medical use of marijuana is the drug’s ill effects on working memory, the ability to transiently hold and process information for reasoning, comprehension and learning. Researchers reporting in the March 2 print issue of the Cell Press journal Cell provide new insight into the source of those memory lapses. The answer comes as quite a surprise: Marijuana’s major psychoactive ingredient (THC) impairs memory independently of its direct effects on neurons. The side effects stem instead from the drug’s action on astroglia, passive support cells long believed to play second fiddle to active neurons.
The findings offer important new insight into the brain and raise the possibility that marijuana’s benefits for the treatment of pain, seizures and other ailments might some day be attained without hurting memory, the researchers say.
With these experiments in mice, "we have found that the starting point for this phenomenon – the effect of marijuana on working memory – is the astroglial cells," said Giovanni Marsicano of INSERM in France.
"This is the first direct evidence that astrocytes modulate working memory," added Xia Zhang of the University of Ottawa in Canada.
The new findings aren’t the first to suggest astroglia had been given short shrift. Astroglial cells (also known as astrocytes) have been viewed as cells that support, protect and feed neurons for the last 100 to 150 years, Marsicano explained. Over the last decade, evidence has accumulated that these cells play a more active role in forging the connections from one neuron to another.
The researchers didn’t set out to discover how marijuana causes its cognitive side effects. Rather, they wanted to learn why receptors that respond to both THC and signals naturally produced in the brain are found on astroglial cells. These cannabinoid type-1 (CB1R) receptors are very abundant in the brain, primarily on neurons of various types.
Zhang and Marsicano now show that mice lacking CB1Rs only on astroglial cells of the brain are protected from the impairments to spatial working memory that usually follow a dose of THC. In contrast, animals lacking CB1Rs in neurons still suffer the usual lapses. Given that different cell types express different variants of CB1Rs, there might be a way to therapeutically activate the receptors on neurons while leaving the astroglial cells out, Marsicano said.
"The study shows that one of the most common effects of cannabinoid intoxication is due to activation of astroglial CB1Rs," the researchers wrote.
The findings further suggest that astrocytes might be playing unexpected roles in other forms of memory in addition to spatial working memory, Zhang said.
The researchers hope to explore the activities of endogenous endocannabinoids, which naturally trigger CB1Rs, on astroglial and other cells. The endocannabinoid system is involved in appetite, pain, mood, memory and many other functions. "Just about any physiological function you can think of in the body, it’s likely at some point endocannabinoids are involved," Marsicano said.
And that means an understanding of how those natural signaling molecules act on astroglial and other cells could have a real impact. For instance, Zhang said, "we may find a way to deal with working memory problems in Alzheimer’s."
###
Han et al.: "Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD."
Contact: Elisabeth (Lisa) Lyons elyons@cell.com 617-386-2121 Cell Press http://www.eurekalert.org/pub_releases/2012-03/cp-hmi022412.php
Return Back To OnlinePot’s Main Medical Page
|