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Cannabis extract Sativex effective in bladder dysfunction in clinical study
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At hospitals in the UK and Belgium 135 patients with multiple sclerosis and overactive bladder were included in a double-blind placebo-controlled, parallel-group trial to study the effect of the cannabis extract Sativex. During 8 weeks they received either the extract or a placebo.
There was only little difference between the cannabis extract and placebo on the primary endpoint, the reduction in daily number of urinary incontinence episodes from baseline to end of treatment. Four out of seven secondary endpoints were significantly in favour of Sativex: number of episodes of urinations (voids) during the night, overall bladder condition, number of voids/day and Patient’s Global Impression of Change. Authors concluded: "Although the primary endpoint did not reach statistical significance, we conclude that Sativex did have some impact on the symptoms of overactive bladder in patients with MS, providing evidence of some improvement in symptoms associated with bladder dysfunction in these subjects."
(Source: Kavia RBC, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ. Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Mult Scler 2010 Sept 9 [in press])
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