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Cannabis Significant Reduces Pain In Randomized Trials, Study Says
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Back To OnlinePot's Main Medical Page
March 31, 2011 -
Toronto, ON, Canada
Toronto,
Ontario:
Cannabis inhalation and the administration of cannabinoids are both associated
with "significant analgesic effects" in the treatment of chronic
non-cancer pain, according to a systemic review
of randomized controlled trials to be published in the British Journal of
Clinical Pharmacology.
Investigators
from the University of Toronto, Hospital for Sick Children, conducted a
literature review regarding the efficacy of cannabinoids in the treatment of chronic
pain, including neuropathic pain, fibromyalgia,
rheumatoid arthritis, and
mixed chronic pain. Eighteen randomized controlled trials published between 2003
and 2010 involving a total of 766 participants met inclusion criteria. Four of
the trials assessed inhaled cannabis, while other studies assessed the analgesic
properties of either plant-derived cannabinoids or synthetic cannabinoids.
"Overall the
quality of trials was excellent," authors wrote. "Fifteen of the
eighteen trials that met inclusion criteria demonstrated a significant analgesic
effect of cannabinoid as compared to placebo, several reported significant
improvements in sleep. There were no serious adverse effects."
Researchers noted
that all
four trials involving inhaled cannabis "found a positive effect with no
serious adverse side effects." They added: "Of special importance is
the fact that two of the trials examining smoked cannabis demonstrated a
significant analgesic effect in HIV neuropathy, a type of pain that has been
notoriously resistant to other treatments normally used for neuropathic pain. In
the trial examining cannabis based medicines in rheumatoid arthritis a
significant reduction in disease activity was also noted, this is consistent
with pre-clinical work demonstrating that cannabinoids are
anti-inflammatory."
Investigators
concluded, "[C]annabinoids are a modestly effective and safe treatment
option for chronic non-cancer (predominantly neuropathic) pain. Given the
prevalence of chronic pain, its impact on function and the paucity of effective
therapeutic interventions, additional treatment options are urgently needed.
More large-scale trials of longer duration reporting on pain and level of
function are required."
For more
information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org.
Full text of the study, "Cannabinoids for treatment of chronic non-cancer
pain; a systemic review of randomized trials," will appear in the British
Journal of Pharmacology.
updated: Mar 31, 2011
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