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The Missoula Study Chronic Cannabis Use in the Compassionate Investigational New Drugs Program
(IND)
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Back To Main Medical Page
In
the spring of 2001 in Missoula, MT, four (Irv Rosenfeld, George McMahon, Elvy
Musikka, and Barbara Douglass) of the 6 remaining federal medical marijuana
patients underwent an extensive three-day examination of every system in their
body to determine the long term effects of cannabis. Known widely as The
Missoula Chronic Use Study, the investigators concluded that after
using cannabis therapeutically for a range of 11 to 27 years, with a dose of
nine cured ounces per month for Barbara and others, and eleven cured ounces
every 26 days for Irv, they were all in fine condition exempting their original
illness and the wear and tear of age. We assume that the federal government
never bothered to conduct such long-term studies because it did not want to
scientifically validate the efficacy of cannabis. A thorough review of the study
was published in the Journal of Cannabis Therapeutics and is available here in
PDF
- Chronic Cannabis Use in the Compassionate Investigational New Drug Program:
An
Examination of Benefits and Adverse Effects of Legal Clinical Cannabis
The
Missoula Study was presented by it’s director, Dr. Ethan Russo at the 2002
Cannabis Therapeutics Conference in Portland, OR.
It is viewable here in full
length, divided into two videos:
Part
One features the legal patients telling their stories, introduced by Mary Lynn
Mathre, President of Patients Out of Time:
Missoula
Study, Part One
Part Two is the
Missoula Study in detail, including MRI scans; chest x-rays and pulminory
function tests; neuro-pychological exams; endocrine and immune system tests;
brain-wave (EEG) tests; hormonal system tests and the "P-300?, an
Evoke-Potential electro-physical test of memory.
Missoula
Study, Part Two
Before
giving results of the "Missoula Study" of four legal medical marijuana
patients, Dr. Ethan Russo first examines the medicine itself - "marijuana
cigarettes" grown at the Univ. of Mississippi; freeze-dried and rolled in
North Carolina; full of broad leaf, stems and seeds.Then the govenment/pharmaceutical alternative - dronabinol (synthetic THC
marketed as Marinol(tm). Largely ineffective, patients also complain about
getting uncomfortably high, as conversion by the liver boosts the psychoactive
levels of THC.
Conclusions
of the Chronic Cannabis Use in the (IND) -
Excerpts:
1. Cannabis smoking, even of a crude, low-grade product, provides
effective symptomatic relief of pain, muscle spasms and intraocular pressure…
2…Cannabis patients are able to reduce or eliminate other prescription
medicines and their accompanying side-effects.
3. Clinical Cannabis provides an improved quality of life…
4. Side effect profile of NIDA Cannabis in chronic usage suggests some mild
pulminary risk.
5. No malignant deteriation has been observed.
6…no neuropsychological or neurological deteriation has been observed.
7. No endocrine, hematological, immunological sequelae have been observed.
Recommendations:
1. Improvements in U.S. clinical Cannabis…sterilized, potent,
organically-grown unfertilized female flower tops…
2…"Compassionate I.N.D." should be reopened and extended…
3…laws amended to provide clinical Cannabis to suitable candidates.
Suggested
Reading:
 Russo,
E. B., Mathre, M. L., Byrne, A., Velin, R., Bach, P. J., Sanchez-Ramos, J., et
al. (2002). Chronic cannabis use in the Compassionate Investigational New Drug
Program: An examination of benefits and adverse effects of legal clinical
cannabis. Journal of Cannabis Therapeutics, 2(1), 3-57.
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Back To Main Medical Page
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